Protein Details: Voltage-gated sodium channel subunit beta-4
Protein ID
ICDB_Pro_0786
Protein Name
Voltage-gated sodium channel subunit beta-4
Gene Name
SCN4B
Organism
Bos taurus (Bovine)
Length
228 amino acids
AlphaFoldDB
AF-Q08E08-F1-model_v4.pdb
Function
Modulates channel gating kinetics. Causes negative shifts in the voltage dependence of activation of certain alpha sodium channels; but does not affect the voltage dependence of inactivation. Modulates the susceptibility of the sodium channel to inhibition by toxic peptides from spider; scorpion; wasp and sea anemone venom (By similarity).
Sequence
MPGARDQGAARARWLGIGLLGLFLLPVSLSLEVSVGKATTIYAVNGTEILLPCTFSSCFGFENLHFWWSYNSSDTYKILIDGTVKNEKSDPKVKLKDDDRITLEGSTKEKMNNISISLKNLEFSDTGKYTCHVKNPKENDFQHQATIFLQVVDKLEEVDNTVTLIILGVVGGVIGLLIFILLVKKFIAFIIKKTQEKKKECLVSSSGNDNTENGLPGSKAEEKAPTKV
PDB Structures
Ligand Binding
Binding Site
Disease
Location
cardiac muscle cell
DOI ID
RefSeq
NP_001070380.1